This is also called smokers disease and involves all the arteries of the body except the heart. It is more common in the legs and is due to narrowing of the arteries causing a reduction of the blood supply to the part it supplies. Over time if the patient continues to smoke the narrowing progressively increases till the artery is totally blocked. The narrowing is due to atherosclerosis, which is the deposition of fat within the walls of the artery called plaque. It is the hardening of the arteries. It is an ageing disease.